What is avacopan?
Avacopan is an oral drug used to treat ANCA associated vasculitis. Avacopan was FDA approved in 2021, and we are still learning how best to use it.
How does avacopan work?
Avacopan is thought to work by blocking the activation and movement of neutrophils – a type of white blood cell involved in ANCA associated vasculitis. It was designed to block a specific part of the immune system called C5a (complement component 5a).
How is avacopan given?
Avacopan is currently used to help reduce the amount of prednisone given during the treatment of active ANCA associated vasculitis. Avacopan is taken by mouth at a dose of 30 mg twice per day.
We pay particular attention to liver function tests during avacopan therapy.
All immunosuppressants require regular monitoring in the form of blood tests, in-person assessments, and prompt attention to any signs or symptoms of infection.