What is apremilast?
Apremilast is an oral drug used in the treatment of Behcet’s disease. Apremilast is specifically approved for the treatment of oral ulcers in Behcet’s disease, and not for other manifestations of Behcet’s.
How does apremilast work?
Apremilast blocks an enzyme called phosphodiesterase 4 which plays a role in inflammation.
How is apremilast given?
The dosing for Behcet’s disease is 30 mg by mouth twice daily. The drug is started gradually according to a standardized escalation plan to reach the final dose of 30 mg twice daily.
Apremilast can cause side effects including diarrhea, nausea, headache, depression, and respiratory infections.
All immunosuppressants require regular monitoring in the form of blood tests, in-person assessments, and vigilance for signs of infection.